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He noted that the FDA and Glaxo did agree on a post-market study called ADOPT, but it was designed to show whether Avandia provided long-term control of blood sugar levels, not to assess whether the drug increases the risk of heart attacks.

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A prominent doctor who sounded an early alarm about a widely used diabetes drug testified yesterday that he was intimidated by the manufacturer when he raised concerns about the drug's safety.

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Avandia was approved on May 25, 1999, and the primary FDA reviewer of the clinical trials submitted recommended approval because the data showed the drug to be effective in reducing blood sugar, however, he also noted that the clinical trials raised questions about Avandia's effect on the heart.

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article updated by Austin ( Sat Apr 26, 2008 11:34:25 GMT )


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